Perimenopause is a systemic inflammatory transition marked by estrogen fluctuation. In hypermobile bodies, mast cells, dysautonomia, and nervous system reactivity can drive widespread inflammation.

For many people with hypermobility, POTS, or other forms of dysautonomia, menopause is when symptoms like dizziness, heat intolerance, and a racing heart suddenly worsen—not because of anxiety, but because hormonal volatility increases the load on an already sensitive nervous system, making thoughtful, physiology-based support essential.