Menopause can disrupt dopamine and nervous system regulation in neurodivergent brains. For people with ADHD, autism, or sensitive systems, estrogen fluctuation can make coping skills stop working.

Perimenopause is a systemic inflammatory transition marked by estrogen fluctuation. In hypermobile bodies, mast cells, dysautonomia, and nervous system reactivity can drive widespread inflammation.

For many people with hypermobility, POTS, or other forms of dysautonomia, menopause is when symptoms like dizziness, heat intolerance, and a racing heart suddenly worsen—not because of anxiety, but because hormonal volatility increases the load on an already sensitive nervous system, making thoughtful, physiology-based support essential.

Premenstrual Dysphoric Disorder (PMDD) is a severe, cyclical condition driven not by abnormal hormone levels, but by an altered brain response to normal hormonal fluctuations—particularly involving serotonin and the progesterone metabolite allopregnanolone. This comprehensive guide reviews evidence-based treatments ranging from antidepressants and hormonal strategies to supplements, cognitive therapies, and mind–body approaches, emphasizing personalized, physiology-informed care.